73 results
Algorithm for the Evaluation and Management of Sickle Cell Crises
Clinical Manifestations and Management

#Diagnosis #Management #Hematology #SickleCell
Algorithm for the Evaluation ... and Management ... of Sickle Cell Crises ... #Diagnosis #Management ... #Hematology #SickleCell
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
test, ANA (e.g., SLE ... (CVID, WAS), (neurologic ... - Bone marrow evaluation ... or if a primary hematologic ... #Workup #hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Prognosis: Usually mild ... Discontinuation of causal ... Usual therapeutic management ... of SLEEvolution ... #diagnosis #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... Positive in 60-80% of cases ... Usual therapeutic management ... of SLEEvolution ... #Summary #rheumatology
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
Management of Lupus ... in 10 to 40% of SLE ... renal histological evaluation ... #rheumatology # ... nephrology
Lupus Nephritis Primer
Class I - Minimal Mesangial
Class II - Mesangial Proliferative
Class Ill - Focal Proliferative
Class IV
Proliferative Class Ill ... Lupus #Nephritis #SLE ... Classification #Classes ... differential #diagnosis #management ... #nephrology
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
valves, COPD, ILD ... body-), PMR, RA, SLE ... Differential #Diagnosis #causes ... #neurology
Cryptogenic Organizing Pneumonia (COP)

Cryptogenic Organizing Pneumonia Overview:
 • Idiopathic form of organizing pneumonia
 • formerly BOOP
other interstitial pneumonias ... Unknown • 6-7 cases ... Hypersensitivity pneumonitis ... BOOP #pulmonary #ILD ... #diagnosis #management
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Scl70 (in some cases ... Scl-70 (in some cases ... , SjS, CTD-ILD, ... body-like: - Neurologic ... differential #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
• Specific for SLE ... Treatment: • Mild ... Erythematosus #SLE ... Summary #diagnosis #rheumatology ... #management