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gammopathy monoclonal oncology syndrome treatment algorithm multiplemyeloma apml arterial autoimmune biopsy classification complications differentiation embolism erythematosus followup hemophilia hodgkins lupus
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS) Mayo Clinic Risk Stratification Model. CBC,
significance (MGUS ... ) Mayo Clinic Risk ... monoclonal #gammopathy #MGUS ... Followup #algorithm #diagnosis ... #management #hematology
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
significance (MGUS ... 1.5 gm/dL) IgM MGUS ... , low-risk MGUS ... Biopsy #algorithm #diagnosis ... #management #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Summary Framework Hematologic ... sub-types based on the hematologic ... isotype (rarely IgD ... #Significance #hematology ... #diagnosis #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
and Management ... : 70 years old, ... and risk-stratification ... • Risks: infection ... #hematology #oncology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
and Management ... may be normal in mild ... Chronic Management ... that ↑ bleeding risk ... #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Diagnosis Framework ... • Acquired Risk ... Ischemic Liver, IBD ... pathophysiology #hematology ... #differential #
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Significance (MGUS ... mediators, including IL ... thromboprophylaxis in high-risk ... Complications #diagnosis ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Attempt if high risk ... opacities • Diagnosis ... initiation • Differential ... Diagnosis: Infection ... #management #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... • Acute lupus pneumonitis ... Thrombosis highest risk ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
• Interstitial Pneumonitis ... effusion, INC risk ... Malignancy Risk ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
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