102 results
Glomerular Tuft on Electron Microscopy

This eyeSCANdy image shows acellular scanning EM of a normal glomerular tuft
Glomerular Tuft ... normal glomerular tuft ... removal of the podocytes ... glomerulus #glomerular #tuft
Glomerular Tuft on Electron Microscopy

This eyeSCANdy image shows acellular scanning EM of a normal glomerular tuft
Glomerular Tuft ... normal glomerular tuft ... removal of the podocytes ... glomerulus #glomerular #tuft
Nephrotic Syndrome - Classification
 - Podocytopathies
 - Immunocomplex Deposits 
 - Other substances Deposits 

#Nephrotic #Syndrome
Immunocomplex Deposits ... Other substances Deposits
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
Nephrotic yndrome—podocyte ... 10 (eg direct podocyte ... damage) or 20 (podocyte
Spectrum of Glomerular Diseases
Nephrotic - Mechanism:
 • Injury to podocytes
 • Changed architecture: Scanning. Deposition of
• Injury to podocytes
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
glomerulopathy (Dense deposit ... Minimal immune deposits
Codocytes (Target cells) - Two target cells are seen in the left photo and one in
Codocytes (Target ... #Blood #Smear #Codocytes
Cutaneous Manifestations of Monoclonal Gammopathy
 • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
Extravascular lg Deposits ... Intravascular lg deposits
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
Presence of immune deposits ... on IF • No EM deposits ... Minimal immune deposits
Innate Immune Cells - Pathophysiology
The innate immune system consists of granulocytes, mast cells, natural killer cells,
killer cells, and monocytes ... Monocytes and neutrophils ... Monocytes and B-cells