44 results
The arrows point to blister cells. These cells are thought to be precursors of helmet cells.
thought to be precursors ... #Clinical #Path ... BloodSmear #Blood #Smear
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing in Hemolytic ... Extravascular Hemolysis ... LDH Peripheral smear ... Carboxyhemoglobin #Hemolytic ... diagnosis #hematology #hemolysis
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... of anemia and hemolysis ... Abnormal peripheral smear ... Immune-mediated Hemolysis ... • Autoimmune Hemolytic
Dacrocytes (tear drop cells) 
Other poikilocytes resemble a pear or teardrop. The narrow, tapered end
may be
thalassemia, and some hemolytic ... #Clinical #Path ... BloodSmear #Blood #Smear
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Antibody Autoimmune Hemolytic ... reticulocytes • Hemolysis ... C3d • Blood smear ... Antibody #Autoimmune #Hemolytic
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... Peripheral blood smear ... Immune mediated hemolysis ... Microangiopathic hemolytic ... UnremarkableLab #Hemolytic
Codocytes (Target cells) - Two target cells are seen in the left photo and one in
associated with hemolytic ... #Clinical #Path ... BloodSmear #Blood #Smear
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic ... or negative - Smear ... C3 positive - Smear ... AIHA #Autoimmune #Hemolytic
Red Blood Cell Morphology Atlas

Size variation, Hemoglobin distribution,  
Hypochromia,  
Shape variation,  
Inclusions, 
Red
#Diagnosis #Path ... #Blood #Smear #
Nucleated red blood cells, aka normoblasts or erythroblasts, were released prematurely from the bone marrow in
maturation of red cell precursors ... #Clinical #Path ... BloodSmear #Blood #Smear