1601 results
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Amyloid precursor protein ... amyloid precursor protein ... chromosome 21) Signs ... geriatrics #diagnosis #signs
Muehrcke's Lines (Leukonychia striata)
Narrow while transverse lines (Not depressed, compared to Beau's lines). Usually 2 or
states of decreased protein ... synthesis or increase protein ... Clinical #Photo #Sign
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Chiari Syndrome - Protein-Losing ... pathophysiology #signs
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
Signs of immunodeficiency ... signal transduction protein ... immunoglobulin proteins ... humoral immunity Signs
Amyloidosis Diagnosis
1) Patient presentation
 • Cardiac-specific signs of amyloidosis: Diastolic heart failure, Heart failure with preserved
Cardiac-specific signs ... • Noncardiac signs ... cardiac-specific signs ... For noncardiac signs ... of monoclonal protein
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
be viral, not proven ... yrs old; F>M Signs ... Pathophysiology #Diagnosis #Signs
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
gene expression/protein ... activates lipolysis Signs
Diagnostic Testing for Meningitis
History:
 • Triad: Fever, neck stiffness, and altered mental status
 • Sens: 44%
Non-specific Kernig Sign ... 95% Brudzinski Sign ... Glucose, WBC, protein
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
myosin and cardiac proteins ... pathophysiology #diagnosis #signs
Risk Factors and Signs of Copper Deficiency
Risk Factors:
 • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
Risk Factors and Signs ... • Medications: Proton ... , Malnutrition Signs ... Deficiency #diagnosis #signs