749 results
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
(Negative urine ... (Positive urine ... albuminuria) - Active urine ... sediment - WBC/RBC casts ... Post-infectious GN - Bland urine
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
RBC casts in urine ... Proteinuria often ... but in severe cases ... Massive proteinuria ... Classification #Proteinuria
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
hematuria and/or proteinuria ... hematuria (RBC casts ... dysmorphic RBCs in urine
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Symptoms of UTI, urine ... WBCs, or urine ... → Urine culture ... glomerular bleeding (proteinuria ... , RBC casts, dysmorphic
Lupus Nephritis - Diagnostic approach to kidney disease associated with systemic lupus erythematosus (SLE)
SLE patient develops
develops new: • Proteinuria ... • Nephritic urine ... dysmorphic RBCs, RBC casts ... , WBC casts) especially ... with evidence of proteinuria
Urinalysis & Urine Sodium 
Theophilus Protospatharius, a seventh-century physician who wrote the first manuscript focused exclusively
Urinalysis & Urine ... exclusively on urine ... proteins, documenting proteinuria ... • Urinary casts ... #UNa #casts #glucosuria
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
overt glomerular proteinuria ... Overglomerular proteinuria ... arbitrarily defined as urine ... cell/white cell casts ... because nephritic urine
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
GN • Active Urine ... dysmorphic RBC, RBC casts ... , +/- proteinuria
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
Hematuria: Red/Dark urine ... 1ml blood/liter urine ... examination of urine ... hematuria: - RBC casts ... - Proteinuria
Causes of Hematuria - Differential Diagnosis Algorithm
Red blood cells on urine microscopy. Must exclude false positives
blood cells on urine ... RBCs and/or RBC casts ... nephrotic range) proteinuria