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hematology coagulation differential abnormal anticoagulation causes dic disseminated intravascular laboratory prolonged ptt anticoagulants apixaban bleeding bruising cascade clinical clot dabigatran
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Step 1: Is the PT ... Patient Receiving Anticoagulants ... Heparin, or Direct Thrombin ... Prolonging the PT ... #prolonged #diagnosis
Effect of Anticoagulants on Coagulation Tests PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Effect of Anticoagulants ... Coagulation Tests PT ... / INR, aPTT, Anti-Xa ... Clotting Time, Thrombin ... Anticoagulation #Testing #Diagnosis
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
at the site of injury ... Thrombin, then primes ... #clot #PT #PTT ... #diagnosis #models ... anticoagulation #anticoagulant
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... to form clots, ... ISTH #Scoring #diagnosis
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal PT ... Prothrombin Time (PT ... heparin - Other anticoagulants ... drugs e.g. direct thrombin ... #Causes #diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... deficiency • Anticoagulants ... warfarin, direct thrombin ... deficiency • Anticoagulant ... #Differential #Diagnosis
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
Algorithm • 12 ... -13 g/dL, • ANC ... iron studies, PT ... /aPTT Differential ... #Algorithm #hematology
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
What's the diagnosis ... Thrombus in transit ... Pt had extensive ... Echocardiogram #A4C ... #Clots #InTransit
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 Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... significant fibrin clot ... Reduction of pro/anticoagulants ... #Coagulation #diagnosis
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