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diagnosis clinical coagulation differential management causes hepatology laboratory abnormal aptt dermatology echocardiogram liver pathophysiology pocus prolonged ptt algorithm blood cascade
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Intravascular Coagulation (DIC ... platelet aggregation PT ... using INR use PT ... small vessels #DIC ... Scoring #diagnosis #hematology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
Prothrombin Time (PT ... Prothrombin Time (PT ... elevated in: • DIC ... thematttsai #PT ... Thromboplastin #laboratory #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Intravascular Coagulation (DIC ... • Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... treatment #management #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
at the site of injury ... FVa to generate thrombin ... Thrombin, then primes ... #clot #PT #PTT ... diagnosis #models #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the PT ... drugs (e.g. direct thrombin ... intravascularcoagulation (DIC ... #differential #hematology
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Step 1: Is the PT ... Heparin, or Direct Thrombin ... Prolonging the PT ... prolonged #diagnosis #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal PT ... Prothrombin Time (PT ... drugs e.g. direct thrombin ... intravascular coagulation (DIC ... #differential #hematology
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
Thrombus in transit ... Pt had extensive ... Echocardiogram #A4C ... PulmonaryEmbolism #Thrombus
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 Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
inhibitors, direct thrombin ... Post-partum • Acute DIC ... comparison #diagnosis #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
== NORMAL PT ... Warfarin • Acute DIC ... disease • Acute DIC ... warfarin, direct thrombin ... Differential #Diagnosis #Hematology
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