17 results
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
Step 1: Is the PT ... Heparin, or Direct Thrombin ... Prolonging the PT ... to identify the cause ... prolonged #diagnosis #hematology
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
Thrombus in transit ... Pt had extensive ... Clinical #POCUS #Echocardiogram ... #A4C #McConnells ... PulmonaryEmbolism #Thrombus
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the PT ... Causes include : ... drugs (e.g. direct thrombin ... #differential #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
at the site of injury ... FVa to generate thrombin ... Thrombin, then primes ... #clot #PT #PTT ... diagnosis #models #hematology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... : Shock Liver, Thrombus ... Differential #Diagnosis #Causes ... Acute #algorithm #hepatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
- Aortic mural thrombus ... considered in all cases ... coagulation and other causes ... Vasculitis • Injury ... pathophysiology #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... drugs e.g. direct thrombin ... aPTT #Prolonged #Causes ... #differential #hematology
Cool echo - RV strain, McConnell sign, and CLOT IN TRANSIT!! BP is normal and pt
is normal and pt ... Clinical #POCUS #Echocardiogram ... #A4C #McConnells ... Pulmonary #Embolism #Thrombus
Constrictive Pericarditis on POCUS Echocardiogram - Subcostal View

Young Lupus patient admitted to hospital new onset HFpEF.
Pericarditis on POCUS Echocardiogram ... could pinpoint the cause ... one month ago-pt ... Pericarditis #CP #POCUS #Echocardiogram ... clinical #cardiology #s4C
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Treat primary cause ... treatment #management #hematology