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diagnosis management coagulation pocus syndrome algorithm anticoagulant anticoagulation apixaban apml cardiac cascade causes clinical clot clots compressions dabigatran dic differential
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
with acute onset CP ... Thrombus in transit ... Pt had extensive ... later with normal LV ... Echocardiogram #A4C
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 Cardiac Standstill on POCUS during CPR A 79yo male presents after being found unresponsive by his wife.
on POCUS during CPR ... lytics in a younger pt ... septal bowing into LV ... dilate to size of LV ... #S4C #Intraarrest
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 Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
12-13 g/dL, • ANC ... LFTs, LDH, ESR, CRP ... iron studies, PT ... Diagnosis #Algorithm #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
FVa to generate thrombin ... Thrombin, then primes ... and endothelial cells ... #clot #PT #PTT ... diagnosis #models #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Release from blast cells ... 5 or elevated Cr ... common • Imaging: CXR ... unless severe APLS ... diagnosis #management #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Schistocytes, helmet cells ... treatment #management #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
, dyspnea, +/- CXR ... have fever - ACS ... Lysis of tumor cells ... acid, Elevated Cr ... diagnosis #management #hematology
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