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hematology abnormal algorithm aptt bleeding prolonged purpura thrombocytopenia arterial blanching bruise dic ecchymosis embolism emergencies hematomas hemeonc hemorrhage hemostasis intravascular
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... / Bruising - Differential ... Diagnosis Algorithm ... Deficiency • Disseminated ... #Differential #
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... #diagnosis #differential ... #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... #diagnosis #causes
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... drugs e.g. direct thrombin ... Disseminated intravascular ... coagulation (DIC ... #diagnosis #differential
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... Diagnosis Framework ... liver failure, disseminated ... discern these causes ... warfarin, direct thrombin
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Arterial Thrombosis - Differential ... Diagnosis Framework ... thrombocytopenia - Disseminated ... intravascular coagulation ... and other causes
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... Hemorrhage - Differential ... Diagnosis Algorithm ... or percreta) Thrombin ... HELLP syndrome • Disseminated
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
ecchymosis) is caused ... Excessive bruising ... to be normal, PT ... Diagnosis VWF ... VWF:RCo/VWF:Ag (differentiate
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... - DIC (disseminated ... intravascular coagulation ... pediatrics #diagnosis ... #differential #
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
rising > 500 → ... first) DIC (disseminated ... intravascular coagulation ... Treat underlying cause ... Oncology #HemeOnc #Diagnosis
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