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hematology coagulation causes differential prolonged clinical clots disseminated echocardiogram intravascular laboratory mcconnells pocus ptt sign anticoagulant anticoagulation apixaban bleeding bruising
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
to Evaluate an Abnormal ... the PT or APTT ... Heparin, or Direct Thrombin ... Prolonging the PT ... #diagnosis #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and the aPTT ... affected in the intrinsic ... drugs (e.g. direct thrombin ... amyloidosis #Abnormal ... #PT #aPTT #Prolonged
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Intravascular Coagulation (DIC ... platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... Congenital intrinsic ... drugs e.g. direct thrombin ... #PT #aPTT #Prolonged ... #Causes #diagnosis
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
What's the diagnosis ... Thrombus in transit ... Pt had extensive ... 3 d later with normal ... Echocardiogram #A4C
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 Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... PT/NORMAL PTT: ... ABNORMAL PT/ ... ABNORMAL PTT: Prolongation
Cool echo - RV strain, McConnell sign, and CLOT IN TRANSIT!! BP is normal and pt
BP is normal and ... pt not in distress ... Echocardiogram #A4C ... Pulmonary #Embolism #Thrombus ... #Clots #InTransit
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 Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... INR < 2.3 - APTT ... #Coagulation #diagnosis
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
FVa to generate thrombin ... along with FXIIa (intrinsic ... Thrombin, then primes ... #clot #PT #PTT ... #diagnosis #models
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
and AST can be normal ... liver glycogen stores ... - Prolonged PT ... As a result of DIC ... Hepatology #Laboratory #Diagnosis
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