13 results
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
of Pregnancy (AFLP ... child * Severe cases ... #AFLP #obstetrics ... #hematology #diagnosis ... #table #comparison
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
coagulation defects. 1) HELLP ... child * Severe cases ... #AFLP #Obstetrics ... #OBGyn #Hematology ... #Diagnosis #Comparison
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
muscle weakness, rash ... pain and/or joint aches ... Myopathies #myopathy #differential ... #diagnosis #comparison ... #rheumatology
Idiopathic Inflammatory Myopathies - 
Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Inclusion Body Myositis ... Idiopathic #Myopathy #Comparison ... Managment #algorithm #Rheumatology ... #Differential
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
, no necrosis HELLP ... of Pregnancy (AFLP ... obstetrics #hepatitis #comparison ... #differential # ... #AFLP
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
Necrotizing Autoimmune Myositis ... Inclusion Body Myositis ... Inflammatory #Myopathies #differential ... #diagnosis #comparison ... #rheumatology #
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Liver Injury - Differential ... • Pregnancy: HELLP ... • AST/ALT > ALP ... Due to synthesis rises ... injury #hepatitis #differential
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Often hard to differentiate ... : TTP has high rates ... thrombocytopenia #Comparison ... Diagnosis #Table #Hematology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
69% - Malar rash ... anemia 4% - Myositis ... (aPL) 30-45% Differential ... symptoms #mimickers #differential ... #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
evidence of (fatigue, rash ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... • Transverse Myelitis ... Erythematosus #Diagnosis #Rheumatology