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hematology anemia hemolytic thrombocytopenia causes hemolysis obstetrics pregnancy ttphus workup algorithm classification extravascular hemolyticuremicsyndrome hus inherited intravascular microangiopathy obgyn platelet
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
and Pregnancy - TTP ... of Pregnancy (AFLP ... child * Severe cases ... #hematology #diagnosis ... #table #comparison
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
of child 3) TTP ... #AFLP #Obstetrics ... #OBGyn #Hematology ... #Diagnosis #Comparison ... #Table
Thrombotic Microangiopathy - TTP VS HUS Big picture points : Often hard to differentiate the two entities,
Often hard to differentiate ... has high rates ... thrombocytopenia #Comparison ... #Diagnosis #Table ... #Hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Fragmentation - MAHA: TTP ... , HUS, DIC, HELLP ... #Diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... • Membrane defects ... Causes: • MAHA: TTP ... , HUS, DIC, HELLP ... #Diagnosis #causes
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... Diagnosis Algorithm ... thrombocytopenia - DIC, TTP ... , HELLP, HUS, aHUS ... #workup #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... coagulation (DIC) - HELLP ... thrombocytopenic purpura (TTP ... Extravascular #Causes #differential ... #diagnosis #hematology
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Qualitative Platelet Defects ... Thrombasthenia • Defect ... #comparison #table ... #differential # ... diagnosis #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... low, tests to detect ... decrease in most cases ... WBC count and differential ... #Workup #Hematology
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