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diagnosis differential hematology algorithm anemia causes management hemolytic pulmonary workup clinical pathophysiology nephrology classification hemoptysis blood hepatology microbiology treatment hyperkalemia
Laboratory Testing in Hemolytic Anemia Intravascular vs Extravascular Hemolysis Reticulocytes Unconjugated bilirubin LDH Peripheral smear Haptoglobin Urine hemosiderin Urine hemoglobin Carboxyhemoglobin #Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing in Hemolytic ... Extravascular Hemolysis ... Reticulocytes ... Carboxyhemoglobin #Hemolytic ... diagnosis #hematology #hemolysis
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... of anemia and hemolysis ... bilirubin • ↑ Reticulocytes ... Immune-mediated Hemolysis ... • Autoimmune Hemolytic
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
peripheral smear, reticulocyte ... Production (↓ reticulocytes ... ↑ Destruction (hemolysis ... , ↑ reticulocytes
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Reticulocyte count ... percentage of reticulocytes ... acute blood loss, hemolysis ... Corrected reticulocyte ... count OR reticulocyte
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Antibody Autoimmune Hemolytic ... normocytic, ↑ reticulocytes ... • Hemolysis: ... Antibody #Autoimmune #Hemolytic
Isolated Hyperbilirubinemia - Differential Diagnosis Algorithm Direct Hyperbilirubinemia: Dubin-Johnson Syndrome, Rotor Syndrome Indirect Hyperbilirubinemia: - Trauma, Hematoma,
, Haptoglobin, Reticulocyte ... , Haptoglobin, Reticulocyte ... Count Abnormal: Hemolysis
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Reticulocyte Production ... days) it takes a reticulocyte ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... EricsMedicalLectures/ #Reticulocyte
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
peripheral smear, a reticulocyte ... specifically order a reticulocyte ... Hemorrhage or hemolysis ... likely cause if the reticulocyte ... elevation in the reticulocyte
General Approach to Anemia - Differential Diagnosis Framework 1) Check reticulocyte count to determine if hypo/hyper-proliferative 2) Exclude
Framework 1) Check reticulocyte ... hyper-proliferative 2) Exclude hemolysis ... hematology #algorithm #reticulocyte
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... abnormal RBCs - Reticulocyte ... Urobilinogen #Hemolysis
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