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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Renal Involvement ... in Systemic Lupus ... #diseases #SLE ... Erythematosus #venn #nephrology ... #nephritis #classification
Algorithm for the Treatment of Membranous Lupus Nephritis
Sub-nephrotic-range proteinuria (<3.5g/d, normal serum albumin) and Preserved kidney
of Membranous Lupus ... SLE 4. ... to treat extra-renal ... SLE • Calcineurin ... Treatment #management #nephrology
Lupus Nephritis Primer
Class I - Minimal Mesangial
Class II - Mesangial Proliferative
Class Ill - Focal Proliferative
Class IV
Lupus Nephritis ... DrFlashHeart #Lupus ... #Nephritis #SLE ... Classification #Classes ... diagnosis #management #nephrology
Lupus Nephritis - Diagnostic approach to kidney disease associated with systemic lupus erythematosus (SLE)
SLE patient develops
Lupus Nephritis ... with systemic lupus ... > 500 mg/d • Nephritic ... , WBC casts) especially ... #nephrology #biopsy
Hyperkalemia: Diagnostic algorithm
Decreased renal potassium excretion
 • Acute renal failure
 • Chronic renal failure
 • Drugs
Increased
• Interstitial nephritis ... • Drugs • Diabetic ... Normal, Renin High ... hypoplasia Aldosterone high ... Diagnosis #algorithm #nephrology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... complements and a high ... APLA/LAC: • Renal ... SSA can rule in SLE ... papillomavirus #SLE
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
exercise or with diuretic ... tubulointerstitial nephritis ... , renal tuberculosis ... Fatty - Nephrotic ... edgarvlermamd - Nephrology
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
Causes of Acute ... at least 50% Renal ... Acute Interstitial Nephritis ... Sjögren) Post-Renal ... #KidneyInjury #Nephrology
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
Management of Lupus ... Nephritis Lupus ... in 10 to 40% of SLE ... or 0.5 g/day → renal ... #rheumatology #nephrology
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Causes of Hypernatremia ... perspiration Renal ... • Nephrogenic diabetes ... #nephrology #sodium ... #high