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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic Lupus ... Microangiopathies #Systemic #Lupus ... Erythematosus #SLE ... #hematology #rheumatology ... #differential #
Lupus Nephritis Primer
Class I - Minimal Mesangial
Class II - Mesangial Proliferative
Class Ill - Focal Proliferative
Class IV
Lupus Nephritis ... DrFlashHeart #Lupus ... #Nephritis #SLE ... Classification #Classes #differential ... diagnosis #management #nephrology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... ) Clinical Manifestations ... Induction Rx: high-dose ... Erythematosus #SLE ... #CNS #neurology
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Hypernatremia - Differential ... diuresis • Central diabetes ... • Nephrogenic diabetes ... Diagnosis #Causes #nephrology ... #sodium #high
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
Vesiculobullous Skin Rash - Differential ... Bullous systemic lupus ... tarda • Diabetic ... Vesiculobullous #SkinRash #dermatology ... #Differential #
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Malar rash • SLE ... IBD • RA • SLE ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #skin #rashes #differential
Causes of Hypernatremia - Differential Diagnosis Algorithm
Hypernatremia - Excess free water loss, Serum Sodium >145 mmol/L
High
Hypernatremia - Differential ... Sodium >145 mmol/L High ... Osmotic diuresis (see ... 300 mmol/kg • Diabetes ... Hypernatremia #Nephrology
High Anion Gap Metabolic Acidosis (HAGMA) - Differential Diagnosis - GOLDMARK

Glycols - ethylene and propylene glycol
Oxoproline
High Anion Gap Metabolic ... Acidosis (HAGMA) - Differential ... Ketoacidosis - diabetic ... Acidosis #HAGMA #Differential ... GOLDMARK #mnemonic #nephrology
Hyperkalemia: Diagnostic algorithm
Decreased renal potassium excretion
 • Acute renal failure
 • Chronic renal failure
 • Drugs
Increased
• Drugs • Diabetic ... Normal, Renin High ... hypoplasia Aldosterone high ... Diagnosis #algorithm #nephrology ... #potassium #differential
Polyuria - Differential Diagnosis Algorithm
Polyuria = >3L Urine output / 24 hours
Urine osmolality = 2 (Na
Polyuria - Differential ... glucose mg/dL]/18 HIGH ... Hyperglycemia, High ... 100 mosm/kg • Diabetes ... Diagnosis #Algorithm #nephrology