25 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... autoantibodies that will cause ... Induction Rx: high-dose ... #CNS #neurology ... cerebritis #diagnosis #management
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... block • Sjogren syndrome ... Severe disease- high ... #Systemic #Lupus ... #rheumatology #management
Lupus Nephritis Primer
Class I - Minimal Mesangial
Class II - Mesangial Proliferative
Class Ill - Focal Proliferative
Class IV
Lupus Nephritis ... #Nephritis #SLE ... Classification #Classes ... differential #diagnosis #management ... #nephrology
High Anion Gap Metabolic Acidosis (HAGMA) - Differential Diagnosis - GOLDMARK

Glycols - ethylene and propylene glycol
Oxoproline
High Anion Gap Metabolic ... with short bowel syndrome ... salicylate toxicity causes ... Ketoacidosis - diabetic ... GOLDMARK #mnemonic #nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... • Fanconi's syndrome ... (MPA) • SLE ... • HTN • Diabetes ... #Proteinuria #Nephrology
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
Causes of HyperKalemia ... • Tumor lysis syndrome ... Succinylcholine • Diabetes ... glycosides • High ... blockers - MCW Nephrology
Causes of Hypernatremia - Differential Diagnosis Algorithm
Hypernatremia - Excess free water loss, Serum Sodium >145 mmol/L
High
Causes of Hypernatremia ... Sodium >145 mmol/L High ... Osmotic diuresis (see ... 300 mmol/kg • Diabetes ... Hypernatremia #Nephrology
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Abnormality • SLE ... heart failure • Diabetes ... • Nephrotic syndrome ... Systemic #Secondary #dermatology ... Diagnosis #Algorithm #causes
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
- Tumor lysis syndrome ... (Uncontrolled diabetes ... insufficiency/Failure • SLE ... differential #diagnosis #causes ... #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
use, Bartter syndrome ... , Gitelman syndrome ... metabolic acidosis • Diabetic ... the indicated causes ... urine #Algorithm #nephrology