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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Renal Involvement ... in Systemic Lupus ... #diseases #SLE ... #Systemic #Lupus ... Erythematosus #venn #nephrology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... severe disease & renal ... Severe disease- high ... #Systemic #Lupus ... #rheumatology #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Induction Rx: high-dose ... Erythematosus #SLE ... #CNS #neurology ... cerebritis #diagnosis #management
Hyperkalemia: Diagnostic algorithm
Decreased renal potassium excretion
 • Acute renal failure
 • Chronic renal failure
 • Drugs
Increased
algorithm Decreased renal ... • Drugs • Diabetic ... Normal, Renin High ... hypoplasia Aldosterone high ... Diagnosis #algorithm #nephrology
Lupus Nephritis Primer
Class I - Minimal Mesangial
Class II - Mesangial Proliferative
Class Ill - Focal Proliferative
Class IV
Lupus Nephritis ... DrFlashHeart #Lupus ... #Nephritis #SLE ... differential #diagnosis #management ... #nephrology
Algorithm for the Treatment of Membranous Lupus Nephritis
Sub-nephrotic-range proteinuria (<3.5g/d, normal serum albumin) and Preserved kidney
of Membranous Lupus ... SLE 4. ... to treat extra-renal ... Algorithm #Treatment #management ... #nephrology
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
perspiration Renal ... diuresis • Central diabetes ... • Nephrogenic diabetes ... Diagnosis #Causes #nephrology ... #sodium #high
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
Management of Lupus ... Nephritis Lupus ... in 10 to 40% of SLE ... or 0.5 g/day → renal ... #rheumatology #nephrology
High Anion Gap Metabolic Acidosis (HAGMA) - Differential Diagnosis - GOLDMARK

Glycols - ethylene and propylene glycol
Oxoproline
High Anion Gap Metabolic ... ketoacidosis Renal ... acids in advanced renal ... Ketoacidosis - diabetic ... GOLDMARK #mnemonic #nephrology
Renal involvement in Systemic Lupus Erythematosus (SLE)

Dr. Laurent ARNAUD @Lupusreference

#Renal #lupus #nephritis #SLE #Systemic #Erythematosus #SLE
Renal involvement ... in Systemic Lupus ... Lupusreference #Renal ... #lupus #nephritis ... #management #treatment