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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic Lupus ... Microangiopathies #Systemic #Lupus ... Erythematosus #SLE ... #hematology #rheumatology ... differential #diagnosis #causes
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 โ€ข Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... Positive in 60-80% of cases ... #lupus #Systemic ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 โ€ข Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... cases, drug-dependent ... Discontinuation of causal ... management of SLE ... #table #rheumatology
Hydroxychloroquine Serum Measurement in SLE
 โ€ข Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... โ€ข Special cases ... #Measurement #SLE ... #rheumatology # ... pharmacology #levels #lupus
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
blisters, possibly crusts ... Bullous systemic lupus ... tarda โ€ข Diabetic ... Vesiculobullous #SkinRash #dermatology ... Diagnosis #Algorithm #causes
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic Lupus ... Erythematosus (SLE ... autoantibodies that will cause ... Erythematosus #SLE ... CNS #neurology #rheumatology
Skin Conditions Associated with Joint Pain

Rash
	โ€ข Human parvovirus B19 infection

Malar rash
	โ€ข SLE
	โ€ข Human parvovirus B19 infection
	โ€ข
Malar rash โ€ข SLE ... IBD โ€ข RA โ€ข SLE ... lesions โ€ข Discoid lupus ... Sarcoidosis #dermatology ... differential #diagnosis #rheumatology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 โ€ข Bacterial
 โ€ข Viral (EBV)
 โ€ข Parasitic
 โ€ข Fungal
Congestive
Causes of Splenomegaly ... Inflammatory โ€ข Systemic Lupus ... Spherocytosis โ€ข Acquired causes ... Diagnosis #Algorithm #Causes ... #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Splenomegaly - CTD (SLE ... Associated - SLE ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
to think about lupus ... pericarditis ยป is...lupus ... children (pediatric SLE ... #diagnosis #sle ... erythematosus #rheumatology