25 results
Algorithm for the Treatment of Membranous Lupus Nephritis
Sub-nephrotic-range proteinuria (<3.5g/d, normal serum albumin) and Preserved kidney
Algorithm for the Treatment ... of Membranous Lupus ... Immunosuppression to treat non-renal ... SLE 4. ... to treat extra-renal
Renal involvement in Systemic Lupus Erythematosus (SLE)

Dr. Laurent ARNAUD @Lupusreference

#Renal #lupus #nephritis #SLE #Systemic #Erythematosus #SLE
Renal involvement ... in Systemic Lupus ... Lupusreference #Renal ... #lupus #nephritis ... #management #treatment
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... nephritis, NPSLE ... • Immunologic Workup ... Positive in 60-80% of cases ... life-threatening • Treatment
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... constitutional symptoms • Treatment ... nephritis, NPSLE ... • Immunologic Workup ... life-threatening • Treatment
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
urinary sediment, renal ... HIV serology, renal ... • Interstitial nephritis ... eosinophiluria, renal ... markers • Cardio-renal
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
Injury (AKI) - Differential ... at least 50% Renal ... IgA, post-strep, lupus ... Acute Interstitial Nephritis ... Sjögren) Post-Renal
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... permanent alopecia Differential ... (nephrotic-range ... APLA/LAC: • Renal ... : Drug induced SLE
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
Management of Lupus ... Nephritis Lupus ... in 10 to 40% of SLE ... or 0.5 g/day → renal ... #treatment #management
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
Common causes of ... thromboembolism, renal ... tumors INTRINSINC RENAL ... Post-infectious GN, Lupus ... Acute Interstitial Nephritis
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... S - Systemic Lupus ... Erythematosus (total 50, renal ... Mnemonic #diagnosis #differential ... #hematology