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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic ... Lupus Erythematosus ... #SLE #hematology ... #rheumatology #differential ... #diagnosis #causes
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... (SLE) Clinical ... Demyelinating Syndrome ... autoantibodies that will cause ... APS), Secondary
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... severe disease & renal ... block • Sjogren syndrome ... severe disease Treatment ... #Lupus #Erythematosus
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Abnormality • SLE ... discoloration) • Chronic renal ... • Nephrotic syndrome ... #Secondary #dermatology ... #Differential #
Renal involvement in Systemic Lupus Erythematosus (SLE)

Dr. Laurent ARNAUD @Lupusreference

#Renal #lupus #nephritis #SLE #Systemic #Erythematosus #SLE
Renal involvement ... in Systemic Lupus ... Lupusreference #Renal ... #SLE #Systemic ... #management #treatment
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
and Primary Causes ... BUN: • Chronic renal ... Myelodisplastic syndrome ... Pruritus #primary #secondary ... #dermatology #Differential
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
thromboembolism, renal ... tumors INTRINSINC RENAL ... nephropathy • Secondary ... GNs: Due to systemic ... Post-infectious GN, Lupus
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... antiphospholipid syndrome ... Lupus Erythematosus ... (total 50, renal ... Mnemonic #diagnosis #differential
Mucous Membrane Disorder - Differential Diagnosis Algorithm
Erosions/Ulcers/Blisters
 - Primary Dermatologic Diseases
     •
Membrane Disorder - Differential ... necrolysis - Systemic ... lupus erythematosus ... #Differential # ... Diagnosis #Algorithm #causes
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... Demyelinating syndromes ... Abdominal pain (20%) Renal ... Thrombocytopenia #Lupus ... #SLE #systemic