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diagnosis rheumatology management symptoms clinical differential erythematosus hematology oncology syndrome classification workup acne alopecia ana anca anesthesia anesthesiology antibodies antibody
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... Sjögrens (15%) Skin ... Butterfly rash, Vasculitis ... #SLE #systemic ... erythematosus #signs
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... severe disease & renal ... Associated with skin ... severe disease Treatment ... #Lupus #Erythematosus
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... inflammation Others: • Lupus ... lupus erythematosus ... purpura: strong sign ... , and SLE) • Urinalysis
Pyoderma Gangrenosum: Autoimmune disorder resulting in a vasculitis which causes slowly progressive ulceration of the skin.
resulting in a vasculitis ... which causes slowly ... ulceration of the skin ... a number of systemic ... #Dermatology #SkinRash
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... hair follicles -> causes ... inflammation on skin ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis #signs
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
antibodies) • Systemic ... lupus erythematosus ... in drug-induced SLE ... ) • Systemic sclerosis ... vasculitis - MPO
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • They can cause ... - Purpura - Skin ... Cryoglobulins Cause ... lupus erythematosus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... Seizures • Strokes Skin ... APLA/LAC: • Renal ... #Systemic #Lupus
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome Systemic ... Oral aphthae : SLE ... • Arthritis: SLE ... Arthritis, AS Treatment ... diagnosis #management #signs
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Episcleritis Signs ... Causes: - Idiopathic ... Leukocytoclastic vasculitis ... ’s syndrome - Lupus ... Treatment: - Systemic
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