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diagnosis rheumatology differential management vasculitis ana antinuclear classification symptoms activation alopecia antibodies antibody antineutrophil autoantibodies comparison cryoglobulinemia cryoglobulins diseases druginduced
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
antibodies) • Systemic ... lupus erythematosus ... in drug-induced SLE ... ) • Systemic sclerosis ... cases • Sjögren syndrome
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Antinuclear (ANA ... severe disease & renal ... block • Sjogren syndrome ... #Lupus #Erythematosus
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
process whereas secondary ... diseases • In secondary ... (PBC), or with systemic ... lupus erythematosus ... (SLE) Signs /
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Diagnosis: • ANCA-associated ... lupus erythematosus ... APLA/LAC: • Renal ... #Systemic #Lupus
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... months to years) Systemic ... Lupus Erythematosus ... • Immunologic Workup ... #table #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... Demyelinating syndromes ... #SLE #systemic ... #erythematosus # ... signs #symptoms
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic ... overlap syndromes ... autoantibodies #Systemic ... #lupus #erythematosus ... #rheumatology #table
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... ischemia - Skin: erythematous ... lupus erythematosus ... purpura: strong sign ... vasculitis, and SLE
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Classified among the secondary ... lupus erythematosus ... lupus erythematosus ... [SLE], AOSD) • ... Diagnosis #Management #Hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Type III Often Secondary ... DDX: • ANCA (Antineutrophil ... lupus erythematosus ... (SLE), rheumatoid
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