51 results
Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic Lupus ... Microangiopathies #Systemic #Lupus ... Erythematosus #SLE ... #hematology #rheumatology ... differential #diagnosis #causes
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... • SLE • CLL ... HELLP Syndrome • TTP ... Diagnosis #Algorithm #Causes ... #Hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... cases, drug-dependent ... • Immunologic Workup ... Discontinuation of causal ... • Immunologic Workup
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
disease - DIC/TTP ... Splenomegaly - CTD (SLE ... Defects: • DIC, TTP ... Associated - SLE ... #nonpalpable #dermatology
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... Microangiopathy: DIC, TTP ... Antibody-mediated: ITP ... - Autoimmune: SLE ... Diagnosis #Framework #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... • Immunologic Workup ... Positive in 60-80% of cases ... #lupus #Systemic
Thrombotic Microangiopathy - TMAs
1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
almost) all TMAs cause ... TMA is due to TTP ... /o significant renal ... catastrophic APS, SRC, SLE ... Microangiopathy #TMAs #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... test, ANA (e.g., SLE ... patients if the cause ... Refractory ITP, ... #Workup #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... fulminans - DIC - TTP ... Autoimmune Vasculitis (lupus ... deficiency Work ... #dermatology #physicalexam
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
Causes of Acute ... at least 50% Renal ... Ethylene glycol) TTP ... IgA, post-strep, lupus ... legionella) • Immune (lupus