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differential rheumatology erythematosus hematology mitral regurgitation secondary symptoms vasculitis algorithm alopecia aortic champs classification comparison complement complications hair hairloss hypocomplementemia
Thrombotic Microangiopathies In Systemic Lupus Erythematosus Dr. Laurent ARNAUD @Lupusreference #TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic ... Lupus Erythematosus ... #SLE #hematology ... #differential #diagnosis ... #causes
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... Pericarditis, Endocarditis ... #SLE #systemic ... erythematosus #signs ... #symptoms #diagnosis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... (SLE): Musculoskeletal ... Myopathy (Also caused ... pathophysiology #signs ... #symptoms #diagnosis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis (>90%) S - Systemic ... Lupus Erythematosus ... subacute bacterial endocarditis ... CHAMPS #Mnemonic #diagnosis
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Abnormality • SLE ... • Bacterial endocarditis ... #Secondary #dermatology ... #Differential #Diagnosis ... #Algorithm #causes
Primary and Secondary Causes of Mitral Regurgitation Primary (organic) chronic mitral regurgitation: • Leaflet: Rheumatic fever, Infective
and Secondary Causes ... cushion defects), Systemic ... inflammation (SLE ... #differential #diagnosis ... #cardiology #causes
Causes of Severe Aortic Regurgitation - Differential Diagnosis Acute: • Leaflet: Traumatic Rupture, Acute Infective Endocarditis, Acute
Causes of Severe ... - Differential Diagnosis ... Inflammatory: Lupus ... Degenerative: Systemic ... #Causes #cardiology
Causes of mitral stenosis Rheumatic heart disease - Most common cause worldwide. Commissural fusion, thick MV leaflets
Secondary to systemic ... leaflets/chordae) - SLE ... disease Infective endocarditis ... #diagnosis #differential ... #cardiology
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
pathognomonic signs ... conditions: Autoimmune (SLE ... features: Fever -, Systemic ... features: Fever +, Systemic ... in up to 30% of cases
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
• Autoimmune (SLE ... Vascular: • Systemic ... Diagnosis? ... + Systemic anticoagulation ... #cardiology
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