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differential rheumatology causes antinuclear erythematosus hematology management autoantibodies classification hairloss symptoms diffuse diseases disorders neurology oncology pathophysiology patterns physicalexam sjogrens
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... Syndrome (SS), ... (SLE), Systemic ... #Antinuclear #Antibodies ... #rheumatology #diagnosis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Syndrome (SS), ... (SLE), Systemic ... (SLE), Systemic ... Arthritis, Sjögren Syndrome ... #rheumatology #diagnosis
Allopecia - Differential Diagnosis Framework for Hair Loss Localized / Focal Hair Loss Pattern: • Scarring Alopecia:
Diagnosis Framework ... , Loose anagen syndrome ... Examination: • Signs ... Vitamin D levels Systemic ... #dermatology #Hairloss
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
) Differential Diagnosis ... Algorithm DIFFUSE ... • Loose anagen syndrome ... #dermatology #Differential ... #Diagnosis #Algorithm
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Female • Peaks 3rd ... permanent alopecia ... Differential Diagnosis ... #Systemic #Lupus
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
: Non-scarring alopecia ... Highly specific antibodies ... Classification #Criteria #SLE ... #Systemic #Lupus ... Erythematosus #diagnosis
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... overlap syndromes ... autoantibodies #Systemic ... #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Auto-Antibodies ... and Lupus Mimickers ... #Systemic #Lupus ... autoantibodies #signs
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus ... (SLE): ANA (anti-nuclear ... others (RNP, aPL antibodies ... • Scleroderma (Systemic ... #Rheumatology #diagnosis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... areas -> Scaring alopecia ... • Red plaques ... pathophysiology #diagnosis ... #signs #symptoms
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