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diagnosis rheumatology erythematosus signs symptoms management hematology oncology chronic classification cll cryoglobulinemia cryoglobulins differential gastrointestinal leukemia lymphocytic manifestations mucocutaneous nonpalpable
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
(PBC), or with systemic ... lupus erythematosus ... (SLE) Signs / ... Xeroderma (Dry skin ... #Syndrome #Pathophysiology
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... - Budd Chiari Syndrome ... #SLE #Gastrointestinal ... #Complications ... #pathophysiology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Associated with skin ... heart block • Sjogren ... polymyositis overlap syndrome ... #Lupus #Erythematosus
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... loss (50%) Eye: Sjögrens ... (15%) Skin (85% ... Demyelinating syndromes ... #SLE #systemic
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Scaring alopecia • Red ... inflammation on skin ... Manifestations #pathophysiology ... signs #symptoms #complications
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Female • Peaks 3rd ... Decade Skin ... dermatomyositis, Sjogren ... #Systemic #Lupus
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... - Purpura - Skin ... reticularis & skin ... lupus erythematosus ... (SLE), rheumatoid
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
associated with systemic ... Musculoskeletal system ... - Lupus - Leukemia ... Treatment: - Systemic ... #diagnosis #dermatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Non-blanchable, dark red ... purple, hemorrhagic skin ... Kasabach-Merritt syndrome ... Associated - SLE ... , Sjogren's
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Lacrimal swelling • Skin ... overlaps with RA, SLE ... enlargement Sjogren's ... Biologic: 2nd or 3rd
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