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diagnosis differential hematology causes management algorithm oncology dermatology hemolytic infectiousdiseases pulmonary vasculitis leukemia signs thrombocytosis acidosis acute autoimmune cardiology clinical
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
of Chronic Disease ... of Chronic Disease ... , Chronic Infection ... #MCV #Classification ... Algorithm #Causes #Hematology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... malignomas, and infectious ... induced by chronic ... dermatomyositis #Size #Classification ... Vessels #Diagnosis #Rheumatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
hemolysis, deficiency anemia ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome ... : Chronic infections
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Myelofibrosis Infectious ... : • Acute or Chronic ... disorders • Celiac disease ... effect following treatment ... Iron deficiency anemia
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
of chronic kidney ... disease, Acute ... Alcohol use, Liver disease ... Myelodysplastic syndrome ... diagnosis #causes #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
deficiencies: Chronic ... kidney disease, ... (e.g. cancer, infection ... G6PD deficiency), Infections ... Production #Index #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
RBCs on Smear • Chronic ... • Anemia of Chronic ... Disease • Marrow ... #Classification ... Algorithm #Causes #Hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Autoimmunity • Chronic ... autoimmune hemolytic anemia ... : • Nephrotic syndrome ... Malignancies • Chronic ... syndrome, HIV)
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... spherocytosis) • Infections ... #anemia
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
Clinical Classification ... - HIV infection ... hemolytic anemia ... Chronic thromboembolic ... Hypertension #PHTN #Classification
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