24 results
diagnosis hematology management differential oncology algorithm syndrome causes hemophagocytic lymphohistiocytosis aplastic chronic cll lymphocytic mds myelodysplastic thrombocytosis activation acute aiha
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Congenital Diseases ... deficiency • Fanconi’s anemia ... Cancer: • Leukemia ... erythematosus • HLH ... deficiency Infections
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Autoimmune diseases ... Adult-onset Still disease ... Unknown cause Treatment ... diagnosis #management #treatment ... #summary #rheumatology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
: • Recurrent infections ... Treatment: • Consider ... to MDS or acute leukemia ... diagnosis #management #treatment ... #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... Alloimmune • anti-HLA ... Vasculitis • Infection ... Algorithm #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Chronic Myelogenous Leukemia ... Myelofibrosis Infectious ... disorders • Celiac disease ... effect following treatment ... Iron deficiency anemia
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... can mimic common infections ... • Bicytopenia Treatment ... : • Infection ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
5) Symptoms of anemia ... Complications: 1) Infection ... chemotherapy for low-risk disease ... marrow failure with anemia ... #oncology #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lymphohistiocytosis (HLH ... SLE], AOSD) • Infection ... with leukopenia, anemia ... Treatment: • Corticosteroids ... #Rheumatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
hemolysis, deficiency anemia ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... TPO, TPO-RA • Infections ... : Chronic infections
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... risk-stratification • Risks: infection ... transformation to acute leukemia ... only curative treatment ... #hematology #oncology
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