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diagnosis differential management rheumatology classification oncology dermatology sle erythematosus hepatology neurology systemic algorithm signs symptoms bruising cardiology cirrhosis cryoglobulinemia fever
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... usually IgG) (e.g. lupus ... differential #diagnosis #hematology ... #anemia
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... Differential #Diagnosis #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... : • Systemic lupus ... Antibody-mediated hemolysis ... Differential #Diagnosis #Hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Butterfly rash, Vasculitis ... Demyelinating syndromes ... pain (20%) Renal disease ... ) Blood (75%): Anemia
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Lemierre's syndrome ... Malignancy: - Hematologic ... . autoimmune): Lupus ... Rheumatoid arthritis, Vasculitis ... the most common vasculitis
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Non-Infectious Aortitis: • Vasculitides ... arteritis, Cogan's Syndrome ... ANCA associated vasculitis ... (RA), Systemic lupus ... Differential #Diagnosis #rheumatology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
and less common diseases ... diagnosis and treatment ... Inflammatory causes ... • Systemic lupus ... ANCA-associated vasculitides
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
blood loss, Acute hemolysis ... , deficiency anemia ... Rebound effect from treatment ... Rheumatologic, Vasculitides ... , IBD, Celiac disease
Etiologies of Peripheral Neuropathy • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism • Medication-induced: ART, Antibiotics,
DiabetesB12 deficiency, Uremia ... Guillain-Barre, Vasculitis ... , Sjogren's, Lupus ... Paraprotein-associated (POEMS syndrome ... differential #diagnosis #causes
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Cold Agglutinin Syndrome ... Viral Infection Clinical ... #hemolytic #anemia ... #hematology #diagnosis
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