27 results
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing in Hemolytic ... Extravascular Hemolysis ... LDH Peripheral smear ... Carboxyhemoglobin #Hemolytic ... diagnosis #hematology #hemolysis
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... of anemia and hemolysis ... Abnormal peripheral smear ... Immune-mediated Hemolysis ... • Autoimmune Hemolytic
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Antibody Autoimmune Hemolytic ... reticulocytes • Hemolysis ... C3d • Blood smear ... Antibody #Autoimmune #Hemolytic
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... Peripheral blood smear ... Immune mediated hemolysis ... Microangiopathic hemolytic ... UnremarkableLab #Hemolytic
Plasmodium Falciparum Blood Smear.
Key features suggesting Plasmodium falciparum:
- extreme parasitemia
- normocytic RBCs (vivax, ovale prefer big
Falciparum Blood Smear ... reticulocytes) - thin trophozoites ... rare in blood smears ... Falciparum #Blood #Smear
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic ... or negative - Smear ... C3 positive - Smear ... AIHA #Autoimmune #Hemolytic
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood Smear ... Microangiopathic hemolytic ... Microspherocytes: Autoimmune hemolytic ... Peripheral #Blood #Smear
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
microangiopathic hemolytic ... Microangiopathic hemolytic ... arrow) Peripheral smear ... microangiopathic #hemolytic ... Hematology #Pathology #Smear
Dacrocytes (tear drop cells) 
Other poikilocytes resemble a pear or teardrop. The narrow, tapered end
may be
thalassemia, and some hemolytic ... BloodSmear #Blood #Smear
Plasmodium falciparum trophozoites (and crenated red blood cells) - Blood Smear

A classic presentation of Plasmodium falciparum
Plasmodium falciparum trophozoites ... cells) - Blood Smear ... falciparum malaria trophozoites ... in a thin blood smear ... falciparum #Blood #Smear