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diagnosis anemia hematology differential algorithm agglutinin ahus aiha analysis anemias antibody atypical blood causes clinical cold disease hemolysis hus interpretation
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Abnormal peripheral smear ... : • Autoimmune ... Hemolytic Anemias ... (AIHAs) • Alloimmune
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... Hemolytic Anemia ... C3d • Blood smear ... Warm #Antibody #Autoimmune ... #Hemolytic #Anemia
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... or negative - Smear ... C3 positive - Smear ... BrighamMedRes #AIHA #Autoimmune ... #Hemolytic #Anemia
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Peripheral blood smear ... Immune mediated hemolysis ... idiopathic, malignancy, autoimmune ... Microangiopathic hemolytic
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood Smear ... Microangiopathic hemolytic ... Microspherocytes: Autoimmune ... hemolytic anemia ... Peripheral #Blood #Smear
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Membrane): - Autoimmune ... Peripheral Blood Smear ... Urobilinogen #Hemolysis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... Diagnosis: • hemolytic ... • Compensated hemolysis ... IgM) • Blood smear ... CLL (older) • Autoimmune
Atypical HUS - Hemolytic Uremic Syndrome Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
Atypical HUS - Hemolytic ... minus diarrhea (autoimmune ... on peripheral smear ... Atypical #HUS #aHUS #Hemolytic
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