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anemia differential algorithm workup management rheumatology autoimmune causes classification criteria erythematosus hemolysis lupus pancytopenia sle testing agglutinin aiha anemias babesia
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... 1) DIAGNOSE AIHA ... C3d • Blood smear ... Pouchelon #Warm #Antibody ... #Anemia #diagnosis
Laboratory Testing in Hemolytic Anemia Intravascular vs Extravascular Hemolysis Reticulocytes Unconjugated bilirubin LDH Peripheral smear Haptoglobin Urine hemosiderin Urine hemoglobin Carboxyhemoglobin #Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing in Hemolytic ... Extravascular Hemolysis ... LDH Peripheral smear ... Testing #workup #diagnosis ... #hematology #hemolysis
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... - Differential Diagnosis ... Abnormal peripheral smear ... #Differential #Diagnosis ... #Algorithm #hematology
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Causes of Hemolytic ... - Differential Diagnosis ... Membrane - Antibody ... #Differential #Diagnosis ... #Causes #hematology
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... or negative - Smear ... C3 positive - Smear ... Pathophysiology #diagnosis ... #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Malaria, Babesiosis, Bartonella ... Peripheral Blood Smear ... #hematology
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
microangiopathic hemolytic ... and laboratory diagnosis ... arrow) Peripheral smear ... #anemia #Hematology ... #Pathology #Smear
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... consider malaria, bartonella ... #Differential #Diagnosis ... Algorithm #workup #hematology
Oroya Fever Hematologic disease caused by Bartonella bacilliformis Restricted to the Andes highlands of Peru & Ecuador B. bacilliformis:
Oroya Fever Hematologic ... disease caused by Bartonella ... lysis → severe hemolytic ... Nodular → Mular DIAGNOSIS ... phase: Peripheral smear
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... Bartonella, Babesia ... udaygulati #Hemolytic ... classification #hematology
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