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diagnosis hematology anemia algorithm hemolysis classification extravascular intravascular management workup aiha anemias antibody calculation cold disease hepatitis hepatology high hodgkins
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential ... Abnormal peripheral smear ... : • Autoimmune ... #Anemias #Differential ... Diagnosis #Algorithm #hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - Differential ... hemoglobinuria) • Cold Agglutinin ... #Hemolytic #Anemia ... Diagnosis #Table #hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... C3d • Blood smear ... : Differential → ... 2) LOOK FOR a cause ... management #treatment #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... . primary cold agglutin ... Extravascular #Causes ... #differential # ... diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... IgM) • Blood smear ... CLL (older) • Autoimmune ... younger pts) Differential ... #anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
- Differential ... Peripheral blood smear ... idiopathic, malignancy, autoimmune ... #Anemia #Differential ... Diagnosis #Algorithm #causes
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... - Differential ... Cold AIHA • Alloimmune ... Extravascular #Differential ... #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Agglutination - Cold agglutinins ... elliptocytosis, autoimmune ... #Anemia #Differential ... Algorithm #workup #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Membrane): - Autoimmune ... Peripheral Blood Smear ... #Differential # ... Diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... - Differential ... iron deficiency, hemolysis ... disorders (e.g. autoimmune ... #hematology #secondary
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