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diagnosis differential algorithm anemia blood clinical microscopy peripheral workup falciparum hemolysis microbiology pathology plasmodium analysis anemias bacilliformis bartonella causes fever
Laboratory Testing in Hemolytic Anemia Intravascular vs Extravascular Hemolysis Reticulocytes Unconjugated bilirubin LDH Peripheral smear Haptoglobin Urine hemosiderin Urine hemoglobin Carboxyhemoglobin #Hemolytic #Anemia #Laboratory #Testing #workup
Extravascular Hemolysis ... bilirubin LDH Peripheral ... smear Haptoglobin ... workup #diagnosis #hematology ... #hemolysis
Plasmodium Falciparum Blood Smear. Key features suggesting Plasmodium falciparum: - extreme parasitemia - normocytic RBCs (vivax, ovale prefer big
Falciparum Blood Smear ... reticulocytes) - thin trophozoites ... ~75% of human malaria ... #peripheral #clinical ... #microbiology #malaria
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Reticulocytes • Abnormal peripheral ... smear Immune-mediated ... Hemolysis: • ... Diagnosis #Algorithm #hematology
Plasmodium falciparum trophozoites (and crenated red blood cells) - Blood Smear A classic presentation of Plasmodium falciparum
cells) - Blood Smear ... Plasmodium falciparum malaria ... in a thin blood smear ... #peripheral #clinical ... #microscopy #malaria
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood ... Smear Analysis ... Microangiopathic hemolytic ... #Blood #Smear # ... Analysis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Hereditary: • Peripheral ... blood smear + DAT ... Immune mediated hemolysis ... Malaria, Clostridium
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... (black arrow) Peripheral ... smear changes are ... #anemia #Hematology ... #Pathology #Smear
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Infections/toxins: Malaria ... Dehydrogenase ↑ - Peripheral ... Blood Smear ↑ abnormal ... Differential #Diagnosis #hematology
Plasmodium vivax on peripheral smear A college student presents w/ headache, fever, chills. Returned 2 days ago
Plasmodium vivax on peripheral ... smear A college ... size amoeboid trophozoite ... PlasmodiumVivax #pvivax #malaria ... #peripheral #smear
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
BMP, uric acid, peripheral ... smear, reticulocyte ... ↑ Destruction (hemolysis ... Diagnosis #Algorithm #hematology
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