10 results
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing in Hemolytic ... Extravascular Hemolysis ... bilirubin LDH Peripheral ... smear Haptoglobin ... Laboratory #Testing #workup
Plasmodium Falciparum Blood Smear.
Key features suggesting Plasmodium falciparum:
- extreme parasitemia
- normocytic RBCs (vivax, ovale prefer big
Falciparum Blood Smear ... reticulocytes) - thin trophozoites ... ~75% of human malaria ... #peripheral #clinical ... #microbiology #malaria
Plasmodium falciparum trophozoites (and crenated red blood cells) - Blood Smear

A classic presentation of Plasmodium falciparum
cells) - Blood Smear ... Plasmodium falciparum malaria ... in a thin blood smear ... #peripheral #clinical ... #microscopy #malaria
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... Hereditary: • Peripheral ... blood smear + DAT ... Immune mediated hemolysis ... Malaria, Clostridium
Plasmodium vivax on peripheral smear
A college student presents w/ headache, fever, chills. Returned 2 days ago
Plasmodium vivax on peripheral ... smear A college ... size amoeboid trophozoite ... PlasmodiumVivax #pvivax #malaria ... #peripheral #smear
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
/uL Initial Workup ... BMP, uric acid, peripheral ... smear, reticulocyte ... ↑ Destruction (hemolysis ... Algorithm #hematology #workup
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Infections/toxins: Malaria ... Dehydrogenase ↑ - Peripheral ... Blood Smear ↑ abnormal ... Urobilinogen #Hemolysis
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
hemorrhage and hemolysis ... intravascular hemolysis ... the range of Peripheral ... blood smear - Shows ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Diagnosis Algorithm Peripheral ... Smear concerning ... hematology for workup ... blood loss, Acute hemolysis
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
by ordering a peripheral ... smear, a reticulocyte ... Hemorrhage or hemolysis ... of the initial work-up ... Homocysteine #Algorithm #Workup