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Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Causes of High-anion ... Hypokalemia ... Hyperkalemia ... Generalized distal nephron ... Chronic progressive kidney
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
Segments of the Nephron ... and their Functions ... organic acids and bases ... #Segments #Function ... #Pathophysiology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Causes of Hypokalemia ... Differential Diagnosis Algorithm ... Differential #Diagnosis #Algorithm ... #causes #potassium ... #low #pathophysiology
Hyperkalemia Differential Diagnosis Algorithm
R/O Pseudo-hyperkalemia:
 • Possible Lab error! Alwavs Repeat Blood sample!
 • Leukocytosis, Thrombocytosis:
Hyperkalemia Differential ... Diagnosis Algorithm ... Differential #Diagnosis #Algorithm ... #causes #potassium ... #high #pathophysiology
Major Physiological Effects of Angiotensin II

Altered Peripheral Resistance
I. Direct vasoconstriction
II. Enhancement of peripheral noradrenergic
neurotransmission:
  A.
Altered Renal Function ... excretion in distal nephron ... neurotransmission in kidney ... AngiotensinII #Pathophysiology ... #Action