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Renal Actions of Diuretics

#Diuretics #Sites #Action #Nephron #Pharmacology #Nephrology
Renal Actions of ... Diuretics #Diuretics ... Sites #Action #Nephron ... #Pharmacology # ... Nephrology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... - Diuretic Sites ... Adenosine #Nephron ... Sites #Action #nephrology ... #pharmacology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Regulating Renal ... Kidney stones caused ... #Renal #Excretion ... #Diuresis #Nephrology ... #Pharmacology #
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Causes of Hypokalemia ... (treatment of diabetic ... Villous adenoma Renal ... chewing tobacco, Renal ... differential #diagnosis #nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
Causes of Hyponatremia ... losses, Diuretic ... Ketonuria, Osmotic diuresis ... Diagnosis #Algorithm #Causes ... #nephrology
Causes of Hypomagnesemia
Redistribution:
 - IV glucose
 - Correction of diabetic ketoacidosis
 - IV hyperalimentation
 - Refeeding
Causes of Hypomagnesemia ... Correction of diabetic ... (steatorrhea) Renal ... Tubulointerstitial renal ... medications #drugs #pharmacology
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Ketoacidosis: Diabetic ... Renal acidosis ... Generalized distal nephron ... Potassium-sparing diuretics ... #nephrology
Causes of Hypomagnesemia
 • Redistribution: IV glucose, Correction of diabetic ketoacidosis, IV hyperalimentation, Refeeding after starvation,
Causes of Hypomagnesemia ... Correction of diabetic ... steatorrhea) • Renal ... Tubulointerstitial renal ... differential #diagnosis #nephrology
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
Segments of the Nephron ... organic acids and bases ... acid and most diuretics ... vasopressin control #Nephron ... Tubules #Table #Pharmacology
Classification of Diabetes Insipidus

Central or neurogenic diabetes insipidus:
 - Congenital - Structural malformations affecting the hypothalamus
Classification of Diabetes ... or neurogenic diabetes ... Acquired - Primary renal ... uropathy, Metabolic causes ... Classification #Types #Nephrology