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Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... of Action Diuretics ... Adenosine #Nephron ... #Pathophysiology ... #Action #nephrology
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
Segments of the Nephron ... and their Functions ... acid and most diuretics ... #Pathophysiology ... #Tubules #Table
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Causes of Hypokalemia ... , nasogastric suction ... thiazide-like diuretics ... , Osmotic diuresis ... #Hypokalemia #Causes
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Causes of High-anion ... Metabolic Acidosis Causes ... and chronic) Causes ... Generalized distal nephron ... Potassium-sparing diuretics
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Diuretics and Agents ... Symport (Loop Diuretics ... Kidney stones caused ... the Nonspecific Cation ... #Medications #Table
Causes of Hypomagnesemia
Redistribution:
 - IV glucose
 - Correction of diabetic ketoacidosis
 - IV hyperalimentation
 - Refeeding
Causes of Hypomagnesemia ... - Nasogastric suction ... Saline or osmotic diuresis ... Drugs: - Loop diuretics ... Hypomagnesemia #Causes
Causes of Hypomagnesemia
 • Redistribution: IV glucose, Correction of diabetic ketoacidosis, IV hyperalimentation, Refeeding after starvation,
Causes of Hypomagnesemia ... loss: Nasogastric suction ... Saline or osmotic diuresis ... • Drugs: Loop diuretics ... Hypomagnesemia #Causes
Major Physiological Effects of Angiotensin II

Altered Peripheral Resistance
I. Direct vasoconstriction
II. Enhancement of peripheral noradrenergic
neurotransmission:
  A.
Altered Renal Function ... excretion in distal nephron ... AngiotensinII #Pathophysiology ... #Action
Treatment of Stable Narrow-Complex Tachycardia
Regular Rhythm:
 • Attempt vagal maneuvers
 • Give adenosine 6 milligrams IV
Treatment of Stable ... B-blockers with caution ... Treat underlying cause ... Treat underlying cause ... management #cardiology #algorithm