Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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Acetaminophen metabolism and factors affecting toxicity. 
GSH = glutathione 

#Acetaminophen #APAP #metabolism #toxicity #Toxicology #Pathophysiology #Overdose
Acetaminophen metabolism ... factors affecting toxicity ... glutathione #Acetaminophen ... APAP #metabolism #toxicity ... #Toxicology #Pathophysiology
Intravenous Lipid Emulsion (ILE) Therapy

ILE is a treatment for severe toxicity from local anesthetics. In addition,
treatment for severe toxicity ... life-threatening toxicity ... #ILE #Therapy #Toxicology ... #Management #Pharmacology
Gamma hydroxybutyrate (GHB) - Toxicology

Clinical presentation
 - Symptoms of GHB toxicity include: short term anterograde amnesia,
hydroxybutyrate (GHB) - Toxicology ... Symptoms of GHB toxicity ... Hydroxybutyrate #GHB #Toxicology ... #Toxicity #Diagnosis ... #Management #Pharmacology
Carbamazepine Toxicity

Carbamazepine (CBZ) is an antiepileptic drug commonly prescribed for seizure disorders, trigeminal neuralgia, neuropathic pain,
Carbamazepine Toxicity ... Carbamazepine #Toxicity ... #Toxicology #Diagnosis ... SideEffects #Adverse #Pharmacology
Utilization of Antibiotics as Antidotes

Valproic Acid Toxicity:
Carbapenems 

Amatoxin Mushrooms: 
Polymyxin B, Penicillin, Cyclosporine

Infographic by Mike O'Brien
@MikeEMPharmD

#Antibiotics
Valproic Acid Toxicity ... Antibiotics #Antidotes #Toxicology ... #Pharmacology
N-Acetyl Cysteine (NAC) Therapy Mechanism of Action: The non-toxic route of APAP metabolism gets saturated in
#Pathophys #Toxicology ... NAcetylCysteine #Acetaminophen ... #Toxicity #emDocs
N-Acetylcysteine (NAC) restores hepatic glutathione!
Found to have 21-28% reduction in mortality for acetaminophen-induced hepatic failure
The earlier
concentration of acetaminophen ... ANY overdose of acetaminophen ... ) #Diagnosis #Toxicology ... #Nomogram #Acetaminophen ... #Toxicity #APAP
Flutycosine - Antibiotics Class Overview
 - 
Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
Thrombocytopenia) and Hepatic toxicity ... monitored to reduce toxicity ... #Pharmacology #Antibiotics ... #Review #Overview
Fomepizole for Acetaminophen Toxicity

 β€’ In cases where fomepizole and NAC were administered together, evidence has
Fomepizole for Acetaminophen ... Toxicity β€’ ... hour equivalent acetaminophen ... #Fomepizole #Acetaminophen ... #Toxicology #pharmacology
Antifungal Azoles - Antibiotics Class Overview

Mechanism:  inhibit ergosterol synthesis (important component of fungal cell membranes)
hepatic, main toxicity ... Isavuconazole(PO or IV) #Pharmacology ... #Antibiotics #Review