Dr. Gerald Diaz @GeraldMD
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Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief πŸ‡΅πŸ‡­ πŸ‡ΊπŸ‡Έ - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 β€’ Normal Acid-Base: Low intake
 β€’ Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Aldosterone: Liddle's Syndrome ... SAME, Cushing Syndrome ... diuretics, Bartter syndrome ... , Gitelman syndrom
Hypokalemia Differential Diagnosis Algorithm

Low intake 
β€’ poor oral intake 

Renal loss 
β€’ Medication 
β€’ Hypomagnesemia 
β€’
Hypokalemia Differential ... Diagnosis Algorithm Low ... β€’ Gitelman's syndrome ... β€’ Bartter's syndrome ... #Differential #
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 β€’ High Al, Low R - Primary aldosteronism
 β€’ High Al, High
Hypokalemia Differential ... acid, Liddle's Syndrome ... R - Cushing's syndrome ... Diuretics, Bartter's syndrome ... , Gitelman's syndrome
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
Aldosterone: Cushing syndrome ... 17alpha-hydroxylase deficiency, Syndrome ... excess, Liddle syndrome ... deficiency, Bartter syndrome ... , Gitelman syndrome
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
↓ Aldosterone: Syndrome ... excess, Liddle's syndrome ... Diuretics, Bartter syndrome ... , Gitelman syndrome ... diagnosis #Algorithm #differential
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 β€’ Purines -> Hypoxanthine /
of Tumor Lysis Syndrome ... -> Uric Acid (low ... Urate Nephropathy (low ... β€’ Hyperkalemia ... #TumorLysis #Syndrome
Causes of Hyponatremia - Differential Diagnosis Algorithm
Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Hyponatremia - Differential ... Diagnosis Algorithm Syndrome ... β€’ Drugs β€’ Pulmonary ... Malignancy True hypovolemia ... β€’ Nephrotic syndrome
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Syndromes and Mimics ... anti-GBM) 10%: - Low ... Antiphospholipid Syndrome ... differentiation syndrome ... #Renal #Syndromes
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
- Differential ... Diuretics, Bartter's syndrome ... , Gitelman's syndrome ... acid, Liddle's syndrome ... β€’ Cushing's syndrome
Cancer agents and Electrolyte Disorders
 β€’ Hypocalcemia: Cisplatin from Low Mg, Cetuximab- due to low Mg
Axitinib,
Disorders β€’ Hypocalcemia ... Ifosfamide - Fanconi syndrome ... Trastuzumab β€’ Hypokalemia ... Ifosfamide - Fanconi syndrome ... chemotherapy #diagnosis #differential