The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
• Serotonin Syndrome ... Dizziness - Nausea ... #SideEffects #Psychiatry ... #Diagnosis #Signs ... #Symptoms
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
Vomiting Serotonin Syndrome ... gain Incr NE: Nausea ... #SideEffects #Psychiatry ... #Diagnosis #Signs ... #Symptoms
Schizophrenia: Pathogenesis and Symptoms
Increased dopaminergic transmission in mesolimbic projection
-> Dopaminergic neurons here project into the limbic
Pathogenesis and Symptoms ... is thought to cause ... is thought to cause ... pathophysiology #diagnosis ... #psychiatry #positive
Post-Traumatic Stress Disorder (PTSD)
Neurochemical abnormalities
 • Hyper-vigilance
 • Emotional hyper-arousal
 • Exaggerated startle reflex
 • Anxiety
Pathophysiology #diagnosis ... #symptoms #signs ... #psychiatry
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
• Withdrawal symptoms ... , tachycardia, nausea ... Pathophysiology #Diagnosis ... #Signs #Symptoms ... #Psychiatry
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Alzheimer's (99% of cases ... mutations - Down syndrome ... chromosome 21) Signs / Symptoms ... pathophysiology #geriatrics #diagnosis ... #signs #symptoms
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
Cauda Equina Syndrome ... Causes: • Large ... spine Signs / Symptoms ... pathophysiology #diagnosis ... #symptoms #signs
Patellofemoral Syndrome - Pathogenesis and clinical findings
 • Anterior Knee Pain with possible symptoms of 'catching'
Patellofemoral Syndrome ... with possible symptoms ... Patellofemoral #Syndrome ... pathophysiology #diagnosis ... #signs #symptoms
Attention Deficit Hyperactive Disorder (ADHD): Pathogenesis and clinical findings
 - For diagnosis, must have either 26
findings - For diagnosis ... to 25 for new diagnosis ... their turn • Causes ... Pathophysiology #diagnosis ... #psychiatry #criteria
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
Clinical Findings Symptoms ... suicide Other Symptoms ... MoodDisorders #Diagnosis ... Pathophysiology #Signs #Symptoms ... #Psychiatry