The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... the pancreas, Vasculitis ... distension #Systemic ... Erythematosus #SLE ... Complications #pathophysiology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... (SLE): Musculoskeletal ... Osteoporosis #Systemic ... Erythematosus #SLE ... Complications #pathophysiology
Systemic Lupus Erythematosus (SLE): Pathogenesis

 • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... (SLE): Pathogenesis ... Multiple immune system ... Erythematosus #SLE ... #Pathophysiology
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
the cause: • Systemic ... Erythematosus (SLE ... Allergy #Immunology #pathophysiology
Feedback Loop: Prolactin (PRL)
 • PRL levels exhibit diurnal, menstrual, and age-related variation
 • TRH has
males • Limbic System ... Libido • Immune System ... #FeedbackLoop #endocrinology ... #pathophysiology
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
(PBC), or with systemic ... arthritis (RA) or systemic ... erythematosus (SLE ... Sjogrens #Syndrome #Pathophysiology
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Livedo Reticularis, Vasculitis ... Phenomenon #Lupus #SLE ... Manifestations #pathophysiology
Upper Urinary Tract infection (UUTI): Pathogenesis and Clinical Findings

Predisposing Factors:
 - Immunocompromised, Diabetes,
 - Elderly, Female
usual defense system ... bacteriuria or cystitis (see ... UrinaryTractInfection #UUTI #Pathophysiology
Menstrual Cycle Physiology: Ovarian Cycle – Luteal Phase Explained
 • The LH surge can be thought
uterine cycle (see ... #OvarianCycle #pathophysiology ... #LutealPhase #endocrinology
Erectile Dysfunction: Pathogenesis

Erectile Dysfunction - Persistent or recurrent inability to achieve an erection sufficient to achieve
and rigidity Endocrinologic ... #Dysfunction #Pathophysiology ... #Urology #Diagnosis