The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
Serotonin #Inhibitors #Pathophysiology ... #SideEffects #Psychiatry ... Diagnosis #Signs #Symptoms
Post-Traumatic Stress Disorder (PTSD)
Neurochemical abnormalities
 • Hyper-vigilance
 • Emotional hyper-arousal
 • Exaggerated startle reflex
 • Anxiety
BehavioralDisorder #Pathophysiology ... #diagnosis #symptoms ... #signs #psychiatry
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
SerotoninNorepinephrine #Inhibitors #Pathophysiology ... #SideEffects #Psychiatry ... Diagnosis #Signs #Symptoms
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
etiology Signs/Symptoms ... GravesDisease #pathophysiology ... #endocin #endocrinology ... #symptoms #signs
Schizophrenia: Pathogenesis and Symptoms
Increased dopaminergic transmission in mesolimbic projection
-> Dopaminergic neurons here project into the limbic
Pathogenesis and Symptoms ... cause the Positive Symptoms ... Schizophrenia #pathophysiology ... #diagnosis #symptoms ... #signs #psychiatry
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
Clinical Findings Symptoms ... suicide Other Symptoms ... MoodDisorders #Diagnosis #Pathophysiology ... #Signs #Symptoms ... #Psychiatry
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Signs/Symptoms: ... Hyperthyroidism #endocrinology ... #pathophysiology
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
• Withdrawal symptoms ... AlcoholUseDisorder #EtOH #Pathophysiology ... Diagnosis #Signs #Symptoms ... #Psychiatry
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... diagnosis #signs #symptoms ... #endocrinology ... #pathophysiology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipolysis Signs/Symptoms ... #FeedbackLoop #endocrinology ... #pathophysiology