The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
destruction), promote inflammation ... Inflammatory #Cascade #Inflammation ... pathophysiology #immunology
Spondylosis - Pathogenesis and Complications

Vertebral disease that may compress the vertebral canal from all sides
Note: Do
Pathogenesis and Complications ... ", which is an inflammation ... pathophysiology #msk #complications
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
manifestations Skin: • Inflammation ... Eyes: • Globe inflammation ... audible Lungs: • Inflammation ... on CXR • RA inflammation ... symptoms #diagnosis #ExtraArticular
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Signs / Symptoms / Complications ... pathophysiology #immunology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
cells or CTLs -> Inflammation ... HypersensitivityReaction #Allergy #Immunology
Lower Urinary Tract Infections: Complications
 - Infection damages the urinary tract epithelium causing fibroblast proliferation and
Tract Infections: Complications ... Bacterial toxins and inflammation ... Pathophysiology #Complications
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Tissue injury and inflammation ... signs #symptoms #complications
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
scaling that extend inflammation ... -> Incr local inflammation ... follicles due to inflammation ... signs #symptoms #complications
Fecal Incontinence - Pathogenesis and Complications
Continence mechanisms are impaired
 • Local neuronal damage
 • External and
Pathogenesis and Complications ... Disorders • Inflammation
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Signs / Symptoms / Complications ... reflex) • Orbital inflammation