The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Spondylosis - Pathogenesis and Complications

Vertebral disease that may compress the vertebral canal from all sides
Note: Do
Pathogenesis and Complications ... ", which is an inflammation ... #Spondylosis #pathophysiology ... #msk #complications
Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
destruction), promote inflammation ... Inflammatory #Cascade #Inflammation ... #pathophysiology ... #immunology
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Signs / Symptoms / Complications ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
Falls: Pathogenesis and Complications
Poly-pharmacy
Disorders affecting movement and balance
 - Sensory deficits
 - Neuromuscular degeneration/Cerebrovascular disease
 -
Pathogenesis and Complications ... Geriatrics #Falls #pathophysiology ... #complications ... #diagnosis
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Tissue injury and inflammation ... RheumaticFever #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
cells or CTLs -> Inflammation ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Lower Urinary Tract Infections: Complications
 - Infection damages the urinary tract epithelium causing fibroblast proliferation and
Tract Infections: Complications ... Bacterial toxins and inflammation ... UrinaryTractInfection #LUTI #Pathophysiology ... #Complications
Fecal Incontinence - Pathogenesis and Complications
Continence mechanisms are impaired
 • Local neuronal damage
 • External and
Pathogenesis and Complications ... Disorders • Inflammation ... Incontinence #geriatrics #pathophysiology
Acute Otitis Media: Complications
Infection and inflammation of the middle ear
 - Prolonged obstruction of e. tube
Otitis Media: Complications ... Infection and inflammation ... Signs/Symptoms/Complications ... #pathophysiology ... symptoms #signs #diagnosis
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
scaling that extend inflammation ... -> Incr local inflammation ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications