The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis signs pediatrics peds acute genetics manifestations otitismedia urology 21hydroxylasedeficiency 21ohd anaphylaxis benign bph bulimianervosa cholesteatoma endocrinology extraarticular incontinence
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs and Symptoms ... Rapid onset of symptoms ... Signs / Symptoms ... / Complications ... pathophysiology #immunology
Ankylosing Spondylitis: Pathogenesis and Clinical findings • Pain in lumbar area and gluteal region: (Dull, insidious
column) • Late complication ... minor trauma #AnkylosingSpondylitis ... diagnosis #signs #symptoms
Acute Otitis Media: Complications Infection and inflammation of the middle ear - Prolonged obstruction of e. tube
Otitis Media: Complications ... Infection and inflammation ... severe Signs/Symptoms ... /Complications ... pathophysiology #symptoms
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Retinoblastoma Signs / Symptoms ... / Complications ... reflex) • Orbital inflammation ... diagnosis #signs #symptoms
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Syndrome Signs/Symptoms ... /Complications: ... • Gonadal hypoplasia
Acute Rheumatic Fever: Pathogenesis and Clinical Findings Delayed autoimmune reaction -> Molecular mimicry -> GAS antigen cross-reacts with host ->
Tissue injury and inflammation ... diagnosis #signs #symptoms ... #complications
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
scaling that extend inflammation ... -> Incr local inflammation ... follicles due to inflammation ... diagnosis #signs #symptoms ... #complications
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
• Cardiac - Inflammation ... - Ligamentous inflammation ... lung fibrosis #AnkylosingSpondylitis ... Manifestations #Complications ... diagnosis #signs #symptoms
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
Benign Prostatic Hyperplasia ... FGF-related proteins) Inflammation ... granulocytes) -> Prostate Inflammation ... Benign #Prostatic #Hyperplasia ... Urology #Signs #Symptoms
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
congenital adrenal hyperplasia ... Signs/Symptoms/Complications
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