The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis signs symptoms manifestations urology allergy ankylosingspondylitis benign bph cascade diabetes diabeticfoot extraarticular fecal geriatrics hyperplasia hypersensitivityreaction lower lupus
Fecal Incontinence - Pathogenesis and Complications Continence mechanisms are impaired • Local neuronal damage • External and
Fecal Incontinence ... Pathogenesis and Complications ... Continence mechanisms ... Disorders • Inflammation ... #Fecal #stool #Incontinence
Anaphylaxis: Pathogenesis Anaphylaxis is a Type 1 hypersensitivity reaction While the primary mechanism of anaphylaxis is mast cell
Anaphylaxis: Pathogenesis ... Anaphylaxis is ... production of inflammatory ... Recruitment of inflammatory ... pathophysiology #immunology
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... cell activity #Inflammatory ... #Cascade #Inflammation ... pathophysiology #immunology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... and Symptoms Anaphylaxis ... Signs / Symptoms / Complications ... Angioedema #Anaphylaxis ... pathophysiology #immunology
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
release the pro-inflammatory ... secretion • Inflammatory ... cells recruited Complications ... conjunctivitis • Anaphylaxis ... HypersensitivityReaction #Allergy #Immunology
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
Mixed Urinary Incontinence ... Urgency Urinary Incontinence ... -> Overflow Incontinence ... (neurogenic), inflammation ... Incr PVR if a complication
Lower Urinary Tract Infections: Complications - Infection damages the urinary tract epithelium causing fibroblast proliferation and
Tract Infections: Complications ... Bacterial toxins and inflammation ... in a systemic inflammatory ... Pathophysiology #Complications
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... follicles due to inflammation ... signs #symptoms #complications
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
photophobia • GI - Inflammatory ... endoscopy (Not Inflammatory ... • Cardiac - Inflammation ... Bladder and bowel incontinence ... Manifestations #Complications
Diabetic Foot: Pathogenesis and clinical findings • Polyol Pathway - Excess glucose enters Polyol pathway ->
dysfunction and inflammation ... arthropathy -> Localized inflammatory ... tissues results in inflammation ... pathophysiology #complications
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