The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis signs ophthalmology acute manifestations otitismedia urology adhesivecapsulitis allergy anaphylaxis ankylosingspondylitis benign bph bulimianervosa cascade centralretinalartery cholesteatoma crao diabetes
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... cell activity #Inflammatory ... #Cascade #Inflammation ... pathophysiology #immunology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs and Symptoms ... Rapid onset of symptoms ... Signs / Symptoms ... / Complications ... pathophysiology #immunology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... diagnosis #signs #symptoms ... #complications
Lower Urinary Tract Infections: Complications - Infection damages the urinary tract epithelium causing fibroblast proliferation and
Tract Infections: Complications ... Bacterial toxins and inflammation ... in a systemic inflammatory ... Pathophysiology #Complications
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
release the pro-inflammatory ... secretion • Inflammatory ... cells recruited Complications ... HypersensitivityReaction #Allergy #Immunology
Acute Otitis Media: Complications Infection and inflammation of the middle ear - Prolonged obstruction of e. tube
Otitis Media: Complications ... Infection and inflammation ... severe Signs/Symptoms ... /Complications ... pathophysiology #symptoms
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Retinoblastoma Signs / Symptoms ... / Complications ... reflex) • Orbital inflammation ... diagnosis #signs #symptoms
Acute Rheumatic Fever: Pathogenesis and Clinical Findings Delayed autoimmune reaction -> Molecular mimicry -> GAS antigen cross-reacts with host ->
Tissue injury and inflammation ... diagnosis #signs #symptoms ... #complications
Psoriatic Arthritis: Complications • Ocular - Inflammation of middle layer of the eye (the uvea, which
Psoriatic Arthritis: Complications ... • Ocular - Inflammation ... Valvular disease - Inflammatory ... diagnosis #signs #symptoms ... #Complications
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
mastoid air cells (inflammation ... mucosa leads to inflammation ... mastoid air cells (inflammation ... : Extension of inflammatory ... pathophysiology #signs #symptoms
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